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Pediatric Infectious Diseases Research Conference

Friday, May 16, 2014,

  • Location: Light Hall • 2215 Garland Avenue • Nashville, TN 37232
  • Room: 512

Rotavirus strategies to take over the antiviral responses of the host cell

Susana Lopez, Ph.D., Professor, Institute of Biotechnology, National University of Mexico

As obligate parasites, viruses depend on the synthetic machinery of the cell to translate their proteins and on the cell energy and building blocks to replicate their genomes. Cells respond to these virus invasions by eliciting diverse responses to eliminate the incoming parasitic agents. In turn, to establish a successful infection, viruses have developed different strategies to take over the cellular metabolic machinery and to cope with the defense mechanisms of the cell. The characterization of this battle has allowed the discovery of the different elements viruses and cells have developed in the attempt to overcome the enemy. As in any other viral infection rotaviruses, the most important cause of acute gastroenteritis in childhood, trigger an antiviral response in their host cell. We are interested in learning how these viruses deal with the different branches of this response that are turned on upon infection. We have found that early on infection rotaviruses induce a shut-off of the cell protein synthesis in which several cellular components of the translation machinery are compromised by the virus. Also, we have found that the OAS-RNAse L system, which is one of the initial antiviral measures of the cell upon sensing dsRNA becomes disabled during rotavirus infection. In this seminar, I will present our recent advances in these topics.