- Location: Wilson Hall • 111 21St Ave S • Nashville, TN 37240
- Room: 115
- Contact: Angel Gaither
- Email: firstname.lastname@example.org
- Phone: 615-322-0080
- Website: https://www.vanderbilt.edu/psychological_sciences/events/index.php
- Audience: Free and Open to the Public
Lucina Uddin, PhD
Director, Brain Connectivity and Cognition Laboratory
Director, Cognitive and Behavioral Neuroscience Division
University of Miami
"Cognitive and neural Flexibility"
Abstract: An optimal amount of variability in neural responses and a balance of brain dynamics across large-scale networks underlie flexible brain function. We recently found evidence that in key nodes of the salience network, brain signal variability shows different lifespan trajectories than most other brain regions. Findings from children with neurodevelopmental conditions including attention-deficit/hyperactivity disorder and autism spectrum disorder suggest that atypical development is characterized by marked alterations in brain signal variability that are related to symptomatology in these disorders. In recent analyses of the salience network, we find evidence for relationships between individual differences in cognitive flexibility that align with specific patterns of brain dynamics. Taken together, these results contribute to an emerging consensus that quantification of brain dynamics and brain signal variability, in addition to more traditional activation analyses, can provide novel insights into the neural mechanisms underlying individual differences in cognitive and behavioral flexibility.