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VICB Seminar, Georgios Skiniotis, Stanford: 'CryoEM Insights Into GPCR acFvaFon and Signaling'

Wednesday, December 05, 2018,

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  • Location: Biological Sciences Building/Medical Research Building (MRB) III • 465 21st Ave S • Nashville, TN 37232
  • Room: 1220

   The Vanderbilt Institute of Chemical Biology (VICB) presents Dr. Georgios Skiniotis, Stanford: "CryoEM Insights Into GPCR acFvaFon and Signaling"

Recent technological breakthroughs have enabled single-particle electron cryo-microscopy (cryoEM) to achieve close to atomic resolution structures of macromolecular complexes. The methodology is now displaying its hidden potential, and has already become a principal choice of method for characterizing the structure of relatively large macromolecular assemblies including membrane receptors. GPCRs and their complexes have been challenging targets for cryo-EM analysis, both because of their dynamic nature and also due to their relatively small size that can limit accurate alignment for 3D reconstructions. Nevertheless, near atomic resolution cryoEM maps of GPCRs are now within reach, opening up unprecedented opportunities to uncover molecular mechanisms and facilitate drug discovery. 

Here, I will give an overview our more recent cryo-EM work to obtain the structures of several pharmacologically important GPCR complexes.