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VICB Seminar, Manfred Lindau, Cornell: 'The Membrane Fusion Nanomachine'

Wednesday, October 03, 2018,

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  • Location: Biological Sciences Building/Medical Research Building (MRB) III • 465 21st Ave S • Nashville, TN 37232
  • Room: 1220

   The Vanderbilt Institute of Chemical Biology presents Dr. Manfred Lindau, Cornell: "The Membrane Fusion Nanomachine"

Key Lecture Points:

· We investigate the molecular mechanism of membrane fusion and transmitter release with specific focus on the steps leading to fusion pore formation.
· We developed a time superresolution technique that beats the time resolution limit of photon statistics and frame duration and identified a rapid change in SNARE complex conformation specifically associated with fusion events.
· Using molecular dynamics simulation we determined a fusion pore structure that has properties that are fully consistent with experimental data. This fusion pore structure reveals a proteo-lipidic fusion pore