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2018 Wendell G. Holladay Lecture In Physics

Thursday, September 13, 2018,

  • Location: 4327 Stevenson Center TN
  • Room: 4327 SC

WENDELL HOLLADAY LECTURE

THURSDAY , September 13, 2018 | 4:00 PM | Stevenson Center 4327*

*Reception @ 3:30 PM | Stevenson Center 6333

 BRADLEY ROTH (Department of Physics, Oakland University)

"The Physics of Mechanotransduction:  How Biological TissueResponds to Mechanical Forces"

Mechanotransduction is the mechanism by which mechanical forces cause biological tissue to grow and remodel. Mechanotransduction can arise from the coupling of the intracellular cytoskeleton to the extracellular matrix by integrin proteins in the cell membrane. A complete description of mechanotransduction requires this idea be expressed using a mathematical model. The mechanical bidomain model treats tissue as a macroscopic continuum, yet accounts for microscopic forces acting on integrins. The model’s central hypothesis is that forces on integrins arise from differences between intracellular and extracellular displacements. This model provides a different view of mechanotransduction than do traditional biomechanics models that do not differentiate between the intra- and extracellular spaces and do not predict forces on integrins. In this talk, I will introduce the bidomain model and use it to interpret experimental data. The model describes the growth of engineered tissue, the remodeling of cardiac tissue around a region of ischemia in the heart, and the differentiation of stem cells in growing cell colonies. This model may impact fields as diverse as development, wound healing, and tumor growth. It is an example of how a simple model grounded in fundamental physics can provide new insights into biological phenomena.

HOST: Prof. John Wikswo

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