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Mark Denison, VUMC: 'Encouraging Infidelity: Antiviral Strategies for MERS and Emerging Coronaviruses'

Wednesday, September 05, 2018,

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  • Location: Biological Sciences Building/Medical Research Building (MRB) III • 465 21st Ave S • Nashville, TN 37232
  • Room: 1220

   The Vanderbilt Institute of Chemical Biology (VICB) presents Dr. Mark Denison, MD, "Encouraging Infidelity: Antiviral Strategies for MERS and Emerging Coronaviruses."

Key Lecture Points:

· Coronaviruses are a family of RNA viruses that have shown remarkable capacity for trans-species movement and emergence, with human potential pandemic pathogens SARS-CoV and currently active MERS-CoV

· Coronaviruses may regulate their replication fidelity (mutations, recombination, resistance) by the functions of the RNA-dependent RNA polymerase and an unprecedented RNA dependent RNA proofreading exonuclease (ExoN

· We have identified nucleoside analog inhibitors that are effective against MERS, SARS and other CoVs even in the setting of ExoN
· The seminar will discuss the activity, mechanisms, resistance and impact on virus fitness of these nucleoside analog inhibitors