- Location: Wilson Hall • 111 21St Ave S • Nashville, TN 37240
- Room: 115
- Contact: Angel Gaither
- Email: email@example.com
- Phone: 615-322-0080
- Website: https://www.vanderbilt.edu/psychological_sciences/events/index.php
- Audience: Free and Open to the Public
Catie Chang, PhD
School of Engineering
"Vigilance states and fMRI signals"
Changes in vigilance are accompanied by prominent changes in brain activity and physiology. However, fluctuations in vigilance are not typically monitored during fMRI, and the expression of these state changes in fMRI measures of activity and connectivity is not fully understood. I will describe studies in which we combined fMRI with electrophysiological and behavioral recordings to investigate fMRI signal dynamics that track vigilance fluctuations. By performing reversible pharmacological inactivation in the macaque, we also examined how cortical fMRI signals linked with vigilance are shaped by specific nuclei in the basal forebrain. Results suggest that characterizing fMRI dynamics linked with internal state changes may improve the extraction of fMRI-based biomarkers.