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Neuroscience Brown Bag Series

Thursday, September 06, 2018,

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  • Location: Wilson Hall • 111 21St Ave S • Nashville, TN 37240
  • Room: 316

Emily Turner, Ph.D.

Postdoctoral Fellow

ASU-Banner Neurodegenerative Disease Research Center

 

"Necroptosis activation in Alzheimer’s disease"

Alzheimer’s disease (AD) is the sixth leading cause of death in the United States, where currently there are more than 5 million case. Given that there are no efficient therapeutic approaches to treat or slowdown the progression of the disease, it is estimated that the number of cases in the United States alone will reach 20 million by 2050 (Alzheimer’s Association, 2015). Profound neuronal loss is an invariable feature of AD; imaging studies and postmortem examinations of AD brains have consistently shown a striking reduction in brain volume and cell number, respectively (Serrano-Pozo et al., 2011; Caselli et al., 2006). However, there is still uncertainty as to the mechanisms of neuronal loss in AD.

 In this talk, I will discuss a wide array of recent published and exciting unpublished findings regarding necroptosis, a form of cell death that is triggered by receptor-interactive protein kinases (RIPK) 1 and 3, and executed by the mixed lineage kinase domain-like (MLKL) protein. Our results provide the first direct evidence that necroptosis is activated in human AD brains as well as in a mouse model of AD that develops neuronal loss, and thus may contribute to neurodegeneration in this insidious disorder (Caccamo et al., 2017).