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Clinical Science Brown Bag Series

Tuesday, April 17, 2018,
  • Location: Wilson Hall • 111 21St Ave S • Nashville, TN 37240
  • Room: 316

Steve Hollon, PhD

Department of Psychology

Vanderbilt University


“Global Mental Health”

Access to adequate mental health care is tenuous at best in the industrialized west but virtually nonexistent in much of the non-industrialized world. Task-shifting represents one effort to deal with this gap. Two studies are presented, one completed and one planned, in rural India in which non-professional lay counselors are used to provide a culturally-adapted behavioral intervention for the treatment of depression. In that first trial the behavioral intervention was superior to enhanced usual care in primary care settings with that advantage maintained across a nine month follow-up. Initial severity moderated the effects of treatment such that participants with more severe depressions derived the greatest differential benefit. The second study involves a planned comparison between the behavioral intervention versus antidepressant medication. The first phase will be used to generate treatment selection algorithms that will then be compared to randomization to the respective mono therapies across the second half of the trial to see if precision medicine can be used to enhance the effects of treatment.