M T W T F S S
    01 02 03 04 05
06 07 08 09 10 11 12
13 14 15 16 17 18 19
20 21 22 23 24 25 26
27 28 29 30 31    
Add An Event

VICB Seminar, Nick Skelton, Genentech, 'Small Molecule Lead Discovery and Optimization at Genentech'

Wednesday, January 24, 2018,

Event Image
  • Location: Biological Sciences Building/Medical Research Building (MRB) III • 465 21st Ave S • Nashville, TN 37232
  • Room: 1220

The Vanderbilt Institute of Chemical Biology (VICB) presents Dr. Nick Skelton, Genentech: "Small Molecule Lead Discovery and Optimization at Genentech"

  

Key Lecture Points
· Multiple approaches and technologies are needed to successfully identify lead compounds for drug discovery
· HTS screening and structure-guided optimization to generate potent and selective inhibition of the kinase AKT (an important oncology target)
· Fragment-based approaches to expand chemical matter for inhibition of NAMPT (a cancer metabolism target)
· Peptide phage-display used to identify ligands for a cryptic binding site on PCSK9 (a target for treating high cholesterol)