Monday, November 20, 2017,
- Location: 1220 MRB III
CDB Monday Seminar Series
Julie Bastarache, M.D. presents “Cell-free hemoglobin increases microvascular permeability in sepsis”
Monday November 20th at 12:15 pm
Room 1220 MRB III
Dr. Bastarache is an Assistant Professor in the Department of Pathology Microbiology and Immunology. Primary faculty are particularly encouraged to attend, to evaluate her suitability as a secondary faculty member of CDB. When I talked with her personally, Dr Bastarache’s research program seemed to align well with the interests of CDB: to understand the pathophysiology of acute respiratory distress syndrome (ARDS) and sepsis and to uncover novel approaches to prevention and treatment of these devastating conditions.
In her talk, “Cell-free hemoglobin increases microvascular permeability in sepsis”, Dr. Bastarache will discuss:
- Increased permeability of the pulmonary microvascular endothelium causes acute pulmonary edema and lung dysfunction in sepsis-associated ARDS.
- Mechanisms regulating microvascular permeability are under intense scrutiny, but proximal triggers of the increased permeability are not well understood.
- Her proposal that cell-free hemoglobin (CFH) released from red blood cells into the circulation during sepsis causes endothelial apoptosis, and increased permeability.