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Molecular Physiology & Biophysics Guest Lecture Series: Ingo H. Greger, PhD

Thursday, November 16, 2017,

  • Location: 206 PRB

Molecular Physiology & Biophysics Guest Lecture Series
Ingo H. Greger, PhD
Programme Leader, Neurobiology Division
MRC Laboratory of Molecular Biology
University of Cambridge

Role of AMPA receptor N-terminal domain in synaptic transmission

 

AMPA‐type glutamate receptors (AMPARs) are tetrameric ca􀆟on channels that are central to

synap􀆟c transmission and plas􀆟city at excitatory synapses. Accumula􀆟on of AMPARs at synap‐

􀆟c sites mediates synap􀆟c poten􀆟a􀆟on and this process ul􀆟mately underlies learning. Recent

progress in AMPAR structural biology and super‐resolu􀆟on light microscopy together with

electrophysiology have resulted in i) a deeper understanding of the mechanics of this dynamic

signalling machine (the AMPAR), and ii) the finding that selec􀆟ve, sub‐synap􀆟c clustering of

AMPARs in nanodomains plays a key role in synap􀆟c poten􀆟a􀆟on. In this talk I will discuss recent

insights into the structural dynamics of AMPARs and how these could play a role in synap

􀆟c anchoring. A key func􀆟on of the AMPAR N‐terminal domain in this anchoring process will

be discussed.

 

Host: Teru Nakagawa, MD, PhD