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Neuroscience Brown Bag Series

Thursday, October 19, 2017,
  • Location: Wilson Hall
  • Room: Room 316

Pooja Balaram, PhD

Harvard Medical School

Mechanisms of homeostatic plasticity in the adult auditory system

Inner ear damage depresses sound-evoked activity in the auditory nerve and brainstem but causes a paradoxical increase in activity in the auditory midbrain, thalamus, and cortex. In some cases, this increase in ‘central gain’ facilitates the recovery of auditory processing and behavioral detection thresholds, despite a significant loss of cochlear input to central auditory structures. In this talk, I will discuss how homeostatic plasticity mechanisms contribute to central gain in the inferior colliculus and auditory cortex of adult mice, in two models of unilateral hearing loss.