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VICB Seminar, Lars Plate, 'Targeting Proteostasis to Treat Amyloid Diseases'

Wednesday, September 13, 2017,
  • Location: Biological Sciences Building/Medical Research Building (MRB) III • 465 21st Ave S • Nashville, TN 37232
  • Room: 1220

The Vanderbilt Institute of Chemical Biology (VICB) presents Dr. Lars Plate, Department of Chemistry, Vanderbilt University: "Targeting Proteostasis to Treat Amyloid Diseases"

Wednesday, September 13, 2017
12:15 P.M. — 1:15 P.M.
1220 MRB III

Key Lecture Points
· Selective activation of Unfolded Protein Response (UPR)-associated transcription factors enhances ER quality control of destabilized proteins associated with amyloid diseases.
· High-throughput screening identifies selective small-molecule activators of distinct UPR-associated transcriptional programs.
· Mass spectrometry-based interactomics uncovers the mechanisms of enhanced ER quality control, revealing emergent properties of ER proteostasis pathways.